SCHEMBL855719

SCHEMBL855719

O=C1OCc2c(Cl)cc(Cl)cc21

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 7/20 0.42
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MAOB P27338 6/20 0.40
MAOA P21397 5/20 0.40
L3MBTL1 Q9Y468 1/20 0.37
CES1 P23141 1/20 0.36
DNMT1 P26358 1/20 0.36
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL855294 0.81 MAOA (0.38) ALOX5MAOBMAOA
SCHEMBL2052507 0.81 ALOX5 (0.41) ALOX5MAOBMAOA
SCHEMBL855938 0.76 ALOX5 (0.39) ALOX5MAOBMAOA
SCHEMBL2041366 0.75 POLB (0.39) ALOX5KMT2AMAOBMAOAL3MBTL1
SCHEMBL8871800 0.74 CES1 (0.49) CES1DNMT1
SCHEMBL29504833 0.73 MAOB (0.47) ALOX5MEN1KMT2AMAOBMAOA
SCHEMBL87504 0.73 MAOB (0.47) ALOX5MEN1KMT2AMAOBMAOA
SCHEMBL854575 0.72 KCNJ1 (0.46) ALOX5MAOBMAOACES1NPC1
SCHEMBL855177 0.72 NUAK1 (0.35) ALOX5MEN1KMT2AMAOB
SCHEMBL23513237 0.72 KCNJ1 (0.42) ALOX5MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105849094-B The manufacture method of halogen-substituted phthalein 住友化学株式会社 2018-04-10 CN disclosed
CN-105849094-A Method for producing halogen-substituted phthalide 住友化学株式会社 2016-08-10 CN disclosed
US-8604221-B2 Production method of halogen-substituted phthalide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-12-10 US disclosed
US-20120142946-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-07 US disclosed
EP-2433933-A1 PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE Sumitomo Chemical Company, Limited (JP) 2012-03-28 EP disclosed