Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.55 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | SCD | O00767 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500317 | 0.79 | SCD (0.54) | PTGS2ALDH1A1SMN1; SMN2ALOX5CSNK1A1 | |
| SCHEMBL6448446 | 0.76 | MAPK14 (0.64) | PTGS2ALDH1A1SMN1; SMN2ALOX5CSNK1A1 | |
| SCHEMBL5144240 | 0.76 | MAPK14 (0.51) | TEKALDH1A1SMN1; SMN2ALOX5CSNK1A1 | |
| SCHEMBL8554519 | 0.76 | PTGS2 (0.47) | PTGS2ALDH1A1SMN1; SMN2ALOX5CSNK1A1 | |
| SCHEMBL5597026 | 0.76 | PTGS2 (0.53) | PTGS2TEKALDH1A1SMN1; SMN2ALOX5 | |
| SCHEMBL6465182 | 0.76 | SCD (0.56) | PTGS2ALDH1A1SMN1; SMN2ALOX5CSNK1A1 | |
| SCHEMBL5501473 | 0.75 | PTGS2 (0.50) | PTGS2TEKALDH1A1SMN1; SMN2ALOX5 | |
| SCHEMBL5597237 | 0.75 | PTGS2 (0.54) | PTGS2ALDH1A1SMN1; SMN2ALOX5CSNK1A1 | |
| SCHEMBL5698677 | 0.75 | ALOX5 (0.74) | PTGS2TEKALDH1A1SMN1; SMN2ALOX5 | |
| SCHEMBL6440993 | 0.74 | PTGS2 (0.52) | PTGS2ALDH1A1SMN1; SMN2ALOX5CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880504-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997027181-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-07-31 | — | — | WO | disclosed |