Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563047 | 0.90 | AVPR1A (0.51) | MAPTRAB9AAVPR1ASMN1; SMN2LMNA | |
| SCHEMBL8563394 | 0.90 | NPC1 (0.50) | MAPTALDH1A1RAB9AAVPR2AVPR1A | |
| SCHEMBL8563279 | 0.89 | AVPR2 (0.48) | ALDH1A1AVPR2AVPR1AKMT2APOLB | |
| SCHEMBL8556562 | 0.88 | KCNK3 (0.44) | AVPR2AVPR1A | |
| SCHEMBL8559901 | 0.87 | AVPR2 (0.63) | AVPR2AVPR1A | |
| SCHEMBL8557883 | 0.85 | MEN1 (0.50) | MAPTALDH1A1RAB9AAVPR2AVPR1A | |
| SCHEMBL8560617 | 0.85 | AVPR1A (0.49) | MAPTRAB9AAVPR2AVPR1ASMN1; SMN2 | |
| SCHEMBL8560629 | 0.84 | SMN1; SMN2 (0.51) | MAPTALDH1A1RAB9AAVPR2AVPR1A | |
| SCHEMBL8558298 | 0.84 | AVPR2 (0.55) | AVPR2AVPR1A | |
| SCHEMBL8563203 | 0.84 | MEN1 (0.47) | MAPTALDH1A1SMN1; SMN2LMNAGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |