SCHEMBL8557699

SCHEMBL8557699

COC(=O)Nc1nc(C)c(C(=O)Cl)s1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LCK P06239 3/20 0.58
ALDH1A1 P00352 5/20 0.51
HTT P42858 2/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
TSHR P16473 2/20 0.48
HPGD P15428 1/20 0.48
RXFP1 Q9HBX9 2/20 0.46
CYP1A2 P05177 1/20 0.46
GAA P10253 1/20 0.46
CYP2C9 P11712 1/20 0.46
POLB P06746 2/20 0.46
MAPT P10636 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ALOX5 P09917 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
LMNA P02545 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8553256 0.85 LCK (0.59) LCKALDH1A1HTTTSHRHPGD
Hydrochloric Acid SCHEMBL8557703 0.83 LCK (0.58) LCKALDH1A1HTTTSHRHPGD
SCHEMBL8555317 0.80 ALDH1A1 (0.76) ALDH1A1HTTMEN1KMT2ATSHR
SCHEMBL8554355 0.75 PIK3CG (0.43) LCKALDH1A1MEN1KMT2AHPGD
SCHEMBL8556702 0.75 MAPK14 (0.48) ALDH1A1HTTMEN1KMT2AHPGD
SCHEMBL23497249 0.74 LCK (0.46) LCKALDH1A1HTTMEN1KMT2A
SCHEMBL3585829 0.74 NPC1 (0.69) LCKALDH1A1MEN1KMT2ARXFP1
SCHEMBL14568864 0.74 LCK (1.00) LCK
SCHEMBL8551752 0.72 LMNA (0.44) LCKALDH1A1MEN1KMT2ARXFP1
SCHEMBL1540075 0.72 LCK (0.64) LCKALDH1A1HTTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0639574-B1 2-aminothiazolecarboxamide derivatives, processes for their preparation and their use for controlling phytopathogenic organisms LUCKY LTD (KR) 1998-06-10 EP disclosed
US-5514643-A FUNGICIDES FOR PLANTS LUCKY LTD. (KR) 1996-05-07 US disclosed
EP-0639574-A1 2-aminothiazolecarboxamide derivatives, processes for their preparation and their use for controlling phytopathogenic organisms LUCKY LTD. (KR) 1995-02-22 EP disclosed