Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cyanate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997144 | 0.91 | ELANE (0.53) | ELANEHSD17B10POLBMAPTPKM | |
| SCHEMBL8557745 | 0.87 | ELANE (0.44) | ELANEHSD17B10POLBMAPTPKM | |
| SCHEMBL9653172 | 0.78 | LMNA (0.41) | ELANEHSD17B10POLBMAPTPKM | |
| SCHEMBL4246590 | 0.74 | CES2 (0.55) | MAPTLMNAMEN1KMT2ARAB9A | |
| SCHEMBL3393415 | 0.73 | TP53 (0.36) | MAPTPKMLMNAESR1ALDH1A1 | |
| SCHEMBL13748694 | 0.72 | ELANE (0.58) | ELANEHSD17B10POLBMAPTPKM | |
| SCHEMBL9652679 | 0.71 | TSHR (0.60) | MAPTPKMNPC1RAB9AGAA | |
| SCHEMBL4248781 | 0.70 | PARP10 (0.56) | HSD17B10MAPTLMNAKMT2ANPC1 | |
| SCHEMBL9339013 | 0.69 | ELANE (0.83) | ELANEHSD17B10POLBMAPTPKM | |
| SCHEMBL269329 | 0.69 | LMNA (0.80) | ELANEHSD17B10POLBMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874809-A1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997025309-A1 | CARBAMOYLOXY DERIVATIVES OF MUTILINE AND THEIR USE AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1997-07-17 | — | — | WO | disclosed |