Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557800 | 0.99 | KDM4E (0.35) | THRATHRBALDH1A1KDM4EMAPT | |
| SCHEMBL8556692 | 0.95 | KDM4E (0.36) | THRATHRBALDH1A1KDM4EMAPT | |
| SCHEMBL8560283 | 0.91 | KDM4E (0.37) | ALDH1A1KDM4EMAPTHPGDPDK2 | |
| SCHEMBL8557627 | 0.87 | PDK2 (0.46) | ALDH1A1KDM4EMAPTHPGDPDK2 | |
| SCHEMBL8555134 | 0.78 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTHPGDPDK2 | |
| SCHEMBL8557956 | 0.75 | TYR (0.47) | KDM4EMAPTGPR84PDK2PPARA | |
| SCHEMBL8559099 | 0.74 | TYR (0.44) | MAPTPDK2PPARAPPARGTSHR | |
| SCHEMBL8559143 | 0.71 | GPR84 (0.36) | THRATHRBKDM4EMAPTHPGD | |
| SCHEMBL8555625 | 0.70 | CYP3A4 (0.43) | ALDH1A1KDM4EMAPTHPGDPDK2 | |
| SCHEMBL8557438 | 0.70 | PDK2 (0.42) | MAPTPDK2PPARAPPARGTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |