Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 3/20 | 0.41 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | CTSG | P08311 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559099 | 0.96 | TYR (0.44) | PDK2TYRELANECTSGMEN1 | |
| SCHEMBL8557956 | 0.94 | TYR (0.47) | PDK2TYRELANECTSGMEN1 | |
| SCHEMBL8556960 | 0.91 | PDK2 (0.44) | PDK2TYRELANECTSGALOX5 | |
| SCHEMBL8552847 | 0.73 | ALDH1A1 (0.41) | PDK2ELANECTSGMEN1MAPT | |
| SCHEMBL8554202 | 0.72 | MEN1 (0.35) | PDK2TYRELANECTSGMEN1 | |
| SCHEMBL8557800 | 0.71 | KDM4E (0.35) | PDK2ELANEMEN1CYP3A4ALOX5 | |
| SCHEMBL8557767 | 0.70 | THRA (0.36) | PDK2ELANEMEN1MAPTTSHR | |
| SCHEMBL8598630 | 0.69 | MEN1 (0.34) | PDK2ELANECTSGMEN1ALOX5 | |
| SCHEMBL2382145 | 0.64 | TYR (0.61) | TYRELANECTSGMEN1TP53 | |
| SCHEMBL167918 | 0.63 | TYR (0.55) | TYRELANECTSGMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |