Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 6/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.50 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 2/20 | 0.31 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208233 | 0.77 | MAPT (0.50) | ALDH1A1 | |
| SCHEMBL9205092 | 0.77 | CDK4 (0.37) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL21831808 | 0.71 | KDM4E (0.32) | KDM4EALDH1A1LMNA | |
| SCHEMBL1419206 | 0.69 | NQO2 (0.34) | CDK4CCND1 | |
| SCHEMBL1451027 | 0.69 | BRPF1 (0.50) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL1450408 | 0.68 | L3MBTL1 (0.34) | KDM4EALDH1A1LMNA | |
| SCHEMBL29967380 | 0.67 | BRPF1 (1.00) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL248619 | 0.67 | BRPF1 (1.00) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL3377086 | 0.67 | CA12 (0.32) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL2593917 | 0.67 | PIK3CD (0.39) | BRPF1BRD4BRD9CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | claimed |
| EP-0462812-B1 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | claimed |
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | claimed |
| EP-0420511-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-08-17 | — | — | EP | claimed |