SCHEMBL8557877

SCHEMBL8557877

COc1ccc2c(c1)c(C(=O)CCCCCBr)cn2C

nearest known ligand 0.49

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.49
MTNR1A P48039 14/20 0.46
MTNR1B P49286 14/20 0.46
NQO2 P16083 1/20 0.46
ADRB2 P07550 1/20 0.44
HTR6 P50406 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7392214 0.85 LMNA (0.42)
SCHEMBL7386302 0.83 OXER1 (0.43)
SCHEMBL7390878 0.82 HTR2A (0.48) ABCG2MTNR1AMTNR1BNQO2
SCHEMBL7284341 0.81 HTR6 (0.60) ABCG2MTNR1AMTNR1BNQO2ADRB2
SCHEMBL7388695 0.80 MTNR1A (0.54) MTNR1AMTNR1BNQO2ADRB2HTR6
SCHEMBL7381802 0.80 LMNA (0.61)
SCHEMBL7392527 0.80 LMNA (0.61)
Hydrochloric Acid SCHEMBL7286402 0.79 HTR6 (0.57) ABCG2MTNR1AMTNR1BNQO2ADRB2
Hydrochloric Acid SCHEMBL7286398 0.79 HTR6 (0.57) ABCG2MTNR1AMTNR1BNQO2ADRB2
SCHEMBL7267209 0.78 MAPT (0.55) ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0873990-A1 BENZOIC ACID COMPOUNDS AND MEDICINAL USE THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1998-10-28 EP disclosed