SCHEMBL7284341

SCHEMBL7284341

COc1ccc2c(c1)c(C(=O)CCN(C)C)cn2C

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 5/20 0.60
ABCG2 Q9UNQ0 1/20 0.51
MAOA P21397 1/20 0.49
MAOB P27338 1/20 0.49
MTNR1A P48039 9/20 0.48
MTNR1B P49286 9/20 0.48
NQO2 P16083 1/20 0.48
ADRB2 P07550 1/20 0.46
ALDH1A1 P00352 2/20 0.45
HSD17B10 Q99714 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
STAT6 P42226 1/20 0.45
THRA P10827 1/20 0.44
THRB P10828 1/20 0.44
KDM4E B2RXH2 1/20 0.44
HPGD P15428 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7286402 0.98 HTR6 (0.57) HTR6ABCG2MAOAMAOBMTNR1A
Hydrochloric Acid SCHEMBL7286398 0.98 HTR6 (0.57) HTR6ABCG2MAOAMAOBMTNR1A
SCHEMBL7278079 0.84 LMNA (0.43) HTR6MAOBALDH1A1HSD17B10CYP1A2
Hydrochloric Acid SCHEMBL7278455 0.83 LMNA (0.43) HTR6MAOBALDH1A1HSD17B10CYP1A2
SCHEMBL7278172 0.82 ALDH1A1 (0.46) HTR6ALDH1A1HSD17B10CYP1A2CYP3A4
Hydrochloric Acid SCHEMBL7278265 0.81 ALDH1A1 (0.45) HTR6MAOBALDH1A1HSD17B10CYP1A2
SCHEMBL8557877 0.81 ABCG2 (0.49) HTR6ABCG2MTNR1AMTNR1BNQO2
SCHEMBL16312903 0.80 ABCG2 (0.61) HTR6ABCG2MTNR1AMTNR1BNQO2
SCHEMBL7278546 0.79 ALDH1A1 (0.64) ALDH1A1HSD17B10CYP1A2CYP3A4CYP2C9
SCHEMBL4406870 0.78 ABCG2 (0.60) HTR6ABCG2MTNR1AMTNR1BNQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0266899-A2 Indole derivatives GLAXO GROUP LIMITED (GB) 1988-05-11 EP disclosed