Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 6/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 4/20 | 0.38 |
| ▸ | RXRG | P48443 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560970 | 0.96 | PTGS1 (0.43) | CA12CA1CA2CA9PTGS1 | |
| SCHEMBL8553646 | 0.92 | CA12 (0.44) | CA12CA1CA2CA9PTGS1 | |
| SCHEMBL8555127 | 0.92 | NPC1 (0.41) | CA12CA1CA2CA9PTGS1 | |
| SCHEMBL9026925 | 0.91 | RXRA (0.44) | CA12CA1CA2CA9PTGS1 | |
| SCHEMBL8557269 | 0.90 | NR4A2 (0.44) | CA12CA1CA2CA9RXRA | |
| SCHEMBL8556746 | 0.89 | GRM5 (0.41) | PTGS1ALOX5RXRAPPARDNR4A2 | |
| SCHEMBL8556036 | 0.88 | NR4A2 (0.43) | CA12CA1CA2CA9PTGS1 | |
| SCHEMBL8555996 | 0.88 | RXRA (0.43) | PTGS1RXRAPTGS2PPARDNR4A2 | |
| SCHEMBL8558777 | 0.86 | TDP1 (0.43) | PTGS1ALOX5RAB9ARXRAPTGS2 | |
| SCHEMBL8560604 | 0.85 | GRM5 (0.41) | PTGS1ALOX5RXRAPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |