Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557667 | 0.88 | SIGMAR1 (0.49) | L3MBTL1EPHX2ACP1SMARCA2SIGMAR1 | |
| SCHEMBL8865952 | 0.79 | EPHX2 (0.48) | EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL8866008 | 0.76 | P2RX7 (0.47) | ALDH1A1EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL8562410 | 0.75 | SIGMAR1 (0.44) | EPHX2SIGMAR1 | |
| SCHEMBL8866420 | 0.75 | EPHX2 (0.47) | EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL8866603 | 0.75 | EPHX2 (0.42) | EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL8867555 | 0.75 | P2RX7 (0.46) | ALDH1A1EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL8558586 | 0.72 | P2RX7 (0.47) | EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL6650826 | 0.71 | P2RX7 (0.61) | EPHX2P2RX7KDM5AKDM5B | |
| SCHEMBL19114039 | 0.70 | P2RX7 (0.39) | DRD3HRH3EPHX2P2RX7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710230-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-09-16 | — | — | EP | disclosed |
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |