Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8866420 | 0.80 | EPHX2 (0.47) | P2RX7EPHX2KDM5AKDM5BMEN1 | |
| SCHEMBL8865952 | 0.78 | EPHX2 (0.48) | P2RX7EPHX2KDM5AKDM5BMEN1 | |
| SCHEMBL17483908 | 0.77 | P2RX7 (0.67) | P2RX7EPHX2 | |
| SCHEMBL6650826 | 0.75 | P2RX7 (0.61) | P2RX7EPHX2KDM5AKDM5BMEN1 | |
| SCHEMBL8866008 | 0.75 | P2RX7 (0.47) | P2RX7EPHX2KDM5AKDM5BMEN1 | |
| SCHEMBL8867555 | 0.74 | P2RX7 (0.46) | P2RX7EPHX2KDM5AKDM5B | |
| SCHEMBL8558652 | 0.74 | SIGMAR1 (0.53) | P2RX7EPHX2KDM5AKDM5BMEN1 | |
| SCHEMBL8866603 | 0.74 | EPHX2 (0.42) | P2RX7EPHX2KDM5AKDM5BMEN1 | |
| SCHEMBL29466655 | 0.74 | ALOX15 (0.47) | EPHX2MEN1KMT2A | |
| SCHEMBL8866573 | 0.74 | ALOX15 (0.47) | EPHX2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710230-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-09-16 | — | — | EP | disclosed |
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |
| US-5686449-A | 1,5-benzodiazepines useful as gastrinor CCK-antagonists | GLAXO WELLCOME S.P.A. (IT) | 1997-11-11 | — | — | US | disclosed |
| CN-1138853-A | 1,5-benzodiazepine derivatives useful as CCK or gastrin antagonists | GLAXO SPA (IT) | 1996-12-25 | — | — | CN | disclosed |
| EP-0710230-A1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO S.p.A. (IT) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003285-A1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO SPA (IT) | 1995-02-02 | — | — | WO | disclosed |