Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | DRD3 | P35462 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8417017 | 0.88 | DRD2 (0.52) | S1PR1DRD2DRD3KDM4EGAA | |
| SCHEMBL177341 | 0.83 | S1PR1 (0.76) | S1PR1DRD2DRD3HDAC1CYP1A1 | |
| SCHEMBL8561767 | 0.81 | S1PR1 (0.45) | S1PR1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL8564103 | 0.80 | S1PR1 (0.42) | S1PR1DRD2DRD3LMNAKMT2A | |
| SCHEMBL1410264 | 0.78 | DRD2 (0.45) | S1PR1DRD2DRD3LMNAHDAC1 | |
| SCHEMBL7281200 | 0.78 | S1PR1 (0.44) | S1PR1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL31662444 | 0.77 | RAB9A (0.47) | S1PR1DRD2DRD3KMT2AMEN1 | |
| SCHEMBL31662551 | 0.77 | DRD2 (0.48) | S1PR1DRD2DRD3RAB9AHDAC1 | |
| SCHEMBL7284261 | 0.76 | HRH2 (0.44) | S1PR1DRD2DRD3KDM4ELMNA | |
| SCHEMBL3712107 | 0.76 | S1PR1 (0.48) | S1PR1DRD2DRD3KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1048490-C | Cyclic derivatives, pharmaceutical compositions containing these compounds and processes for preparing them | THOMAE GMBH DR K (DE) | 2000-01-19 | — | — | CN | disclosed |
| US-5827849-A | HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT | KARL THOMAE GMBH (DE) | 1998-10-27 | — | — | US | disclosed |
| EP-0612741-B1 | Cyclic derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-06-10 | — | — | EP | disclosed |
| US-5612335-A | ANTICOAGULANTS; COMBATING/PREVENTING DISEASES WHERE CELL AGGREGATES OCCUR OR CELL-MATRIX INTERACTIONS PLAY A PART | KARL THOMAE GMBH (DE) | 1997-03-18 | — | — | US | disclosed |
| US-5519036-A | IMIDAZOLIDINONES, ANTICOAGULANTS, CELL AGGREGATION PREVENTION | KARL THOMAE GMBH (DE) | 1996-05-21 | — | — | US | disclosed |
| EP-0612741-A1 | Cyclic derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-08-31 | — | — | EP | disclosed |