SCHEMBL8564103

SCHEMBL8564103

CCOC(=O)CCN1CCN(c2ccc(-c3ccc4c(c3)CCN(C)CC4)cc2)C1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 1/20 0.42
TMEM97 Q5BJF2 3/20 0.40
SIGMAR1 Q99720 3/20 0.40
SLC6A2 P23975 2/20 0.40
HRH2 P25021 2/20 0.40
HRH1 P35367 2/20 0.40
HTR1A P08908 1/20 0.40
CHRM5 P08912 1/20 0.40
ADRA1D P25100 1/20 0.40
HTR1B P28222 1/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR1E P28566 1/20 0.40
HTR2B P41595 1/20 0.40
SLC6A3 Q01959 1/20 0.40
DRD2 P14416 3/20 0.38
DRD3 P35462 3/20 0.38
RAB9A P51151 3/20 0.38
NPC1 O15118 2/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8557146 0.85 S1PR1 (0.53) S1PR1DRD2DRD3POLBMEN1
SCHEMBL7479149 0.82 ITGB3 (0.40) S1PR1TMEM97SIGMAR1SLC6A2HRH2
SCHEMBL7474127 0.82 TMEM97 (0.43) S1PR1TMEM97SIGMAR1SLC6A2HRH2
SCHEMBL8558181 0.80 S1PR1 (0.50) S1PR1DRD2DRD3RAB9ALMNA
SCHEMBL8560515 0.79 CYP4F2 (0.45) S1PR1TMEM97SIGMAR1SLC6A2HRH2
SCHEMBL8417017 0.79 DRD2 (0.52) S1PR1DRD2DRD3RAB9ANPC1
Hydrochloric Acid SCHEMBL8563637 0.78 CYP4F2 (0.44) S1PR1TMEM97SIGMAR1SLC6A2HRH2
Hydrochloric Acid SCHEMBL7420584 0.76 S1PR1 (0.54) S1PR1HTR2ADRD2DRD3POLB
SCHEMBL7469768 0.75 MAPT (0.41) S1PR1TMEM97SIGMAR1SLC6A2HRH2
SCHEMBL7474006 0.74 ITGB3 (0.38) S1PR1TMEM97SIGMAR1SLC6A2HRH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5827849-A HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT KARL THOMAE GMBH (DE) 1998-10-27 US disclosed
EP-0612741-B1 Cyclic derivatives, medicaments containing them and process for their preparation THOMAE GMBH DR K (DE) 1998-06-10 EP disclosed
US-5612335-A ANTICOAGULANTS; COMBATING/PREVENTING DISEASES WHERE CELL AGGREGATES OCCUR OR CELL-MATRIX INTERACTIONS PLAY A PART KARL THOMAE GMBH (DE) 1997-03-18 US disclosed
US-5519036-A IMIDAZOLIDINONES, ANTICOAGULANTS, CELL AGGREGATION PREVENTION KARL THOMAE GMBH (DE) 1996-05-21 US disclosed
EP-0612741-A1 Cyclic derivatives, medicaments containing them and process for their preparation Dr. Karl Thomae GmbH (DE) 1994-08-31 EP disclosed