Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559668 | 0.94 | ALPL (0.36) | RXRAALPLALDH1A1MAPTALOX5AP | |
| SCHEMBL8560361 | 0.93 | RXRA (0.46) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8561044 | 0.92 | NPC1 (0.38) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8555128 | 0.89 | MAPT (0.35) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8556682 | 0.88 | RPS6KA2 (0.43) | RXRACA12CA1CA2CA9 | |
| SCHEMBL8554064 | 0.88 | RXRA (0.40) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8557881 | 0.87 | ALPL (0.36) | ALPLALDH1A1MAPTALOX5APFEN1 | |
| SCHEMBL8560516 | 0.87 | FAAH (0.36) | NR4A2ALDH1A1MAPTALOX5APFEN1 | |
| SCHEMBL8558684 | 0.87 | RXRA (0.46) | RXRANPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL8556834 | 0.87 | MAPT (0.35) | RXRANPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |