Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9834624 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRKDM4ENPSR1CYP1A2 | |
| SCHEMBL9832445 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRKDM4ENPSR1CYP1A2 | |
| SCHEMBL1742675 | 0.69 | LMNA (0.53) | SMN1; SMN2TSHRKDM4ECYP1A2POLB | |
| SCHEMBL9866247 | 0.68 | PKM (0.34) | SMN1; SMN2TSHRKDM4ECYP1A2CYP2C9 | |
| SCHEMBL8558004 | 0.68 | TSHR (0.33) | SMN1; SMN2TSHRKDM4ENPSR1KDM5B | |
| SCHEMBL10490335 | 0.68 | ALDH1A1 (0.45) | SMN1; SMN2TSHRKDM4ECYP1A2POLB | |
| SCHEMBL9665767 | 0.68 | CA12 (0.31) | — | |
| SCHEMBL9679579 | 0.68 | CKS1B (0.42) | SMN1; SMN2TSHRKDM4EPOLB | |
| SCHEMBL9830226 | 0.67 | — | — | |
| SCHEMBL10490362 | 0.67 | TP53 (0.42) | SMN1; SMN2KDM4ECYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0537611-B1 | Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides | DOW AGROSCIENCES LLC (US) | 1998-08-12 | — | — | EP | disclosed |
| EP-0537611-A1 | Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides | DOWELANCO (US) | 1993-04-21 | — | — | EP | disclosed |
| US-5177206-A | Process for the preparation of substituted N-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides | DOWELANCO (US) | 1993-01-05 | — | — | US | disclosed |
| US-5003096-A | Alkylsilylaniline intermediates for herbicides | THE DOW CHEMICAL COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| US-4910306-A | Combining a sulfonyl halide with N-trialkylsilylaniline | THE DOW CHEMICAL COMPANY (US) | 1990-03-20 | — | — | US | disclosed |