Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 2/20 | 0.35 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL194481 | 0.84 | LMNA (0.43) | SMN1; SMN2LMNAMAPTALOX15KDM4E | |
| Propionic Acid SCHEMBL28455719 | 0.76 | ALDH1A1 (0.37) | SMN1; SMN2LMNAMAPTALOX15HSD17B10 | |
| SCHEMBL10627854 | 0.73 | LMNA (0.34) | SMN1; SMN2LMNAMAPTALOX15KDM4E | |
| SCHEMBL1980670 | 0.71 | LMNA (0.58) | SMN1; SMN2LMNAMAPTSLC40A1ALOX15 | |
| Phthalimide SCHEMBL28230143 | 0.69 | ALDH1A1 (0.63) | GSK3BCASP3CASP2CASP7CASP6 | |
| SCHEMBL11497898 | 0.67 | MAP4K4 (0.33) | SMN1; SMN2LMNAMAPTALOX15KDM4E | |
| Phthalimide SCHEMBL28134165 | 0.65 | GSK3B (0.83) | GSK3BCASP3CASP2CASP7CASP6 | |
| SCHEMBL31253020 | 0.64 | CCR1 (0.70) | SMN1; SMN2LMNAMAPTALOX15KDM4E | |
| SCHEMBL18099777 | 0.64 | CCR1 (0.70) | SMN1; SMN2LMNAMAPTALOX15KDM4E | |
| SCHEMBL8669721 | 0.64 | KDM4E (0.40) | LMNAMAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792874-A | Process for the manufacture of 8-chloro-6-(2-flourophenyl)-1-methyl-4H-imidazo 1,5A! 1,4!benzodiazepine (midazolam) | RANBAXY LABORATORIES, LTD. (IN) | 1998-08-11 | — | — | US | disclosed |
| US-5756729-A | Process for the manufacture of 8-chloro-6 (2-fluorophenyl)-1 methyl-4H-imidazo 1,5a! 1,4! benzodiazepine (midazolam) | RANBAXY LABORATORIES, LTD. (IN) | 1998-05-26 | — | — | US | disclosed |
| EP-0835874-A2 | A process for the manufacture of 8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo (1,5a)(1,4) benzodiazepine (midazolam) | RANBAXY LABORATORIES, LTD. (IN) | 1998-04-15 | — | — | EP | disclosed |