Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | CCR1 | P32246 | 4/20 | 0.58 |
| ▸ | CCR8 | P51685 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | CCR5 | P51681 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8585181 | 0.83 | MAPT (0.46) | LMNACCR1CCR8KDM4EMAPT | |
| SCHEMBL31418346 | 0.81 | LMNA (0.73) | LMNACCR1CCR8KDM4EMAPT | |
| SCHEMBL5789671 | 0.81 | LMNA (0.73) | LMNACCR1CCR8KDM4EMAPT | |
| Phenanthroline SCHEMBL9343811 | 0.78 | KDM4E (0.84) | LMNACCR1CCR8KDM4EMAPT | |
| SCHEMBL194481 | 0.77 | LMNA (0.43) | LMNACCR1CCR8KDM4EMAPT | |
| Phenanthroline SCHEMBL27878295 | 0.76 | KDM4E (0.80) | LMNACCR1CCR8KDM4EMAPT | |
| Phenanthroline SCHEMBL29013283 | 0.75 | CCR1 (0.89) | LMNACCR1CCR8KDM4EMAPT | |
| Phenanthroline SCHEMBL29354015 | 0.75 | CCR1 (1.00) | LMNACCR1CCR8KDM4EMAPT | |
| Phenanthroline SCHEMBL8845760 | 0.75 | CCR1 (1.00) | LMNACCR1CCR8KDM4EMAPT | |
| Phenanthroline SCHEMBL8312 | 0.75 | CCR1 (1.00) | LMNACCR1CCR8KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509981-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | LILLY CO ELI (US) | 2014-08-06 | — | — | EP | disclosed |
| US-8796260-B2 | Imidazobenzazepine CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-08-05 | — | — | US | disclosed |
| US-8796260-B2 | Imidazobenzazepine CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2014-08-05 | — | — | US | disclosed |
| EP-1401838-B1 | NOVEL SUBSTITUTED TETRACYCLIC IMIDAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2014-03-26 | — | — | EP | disclosed |
| US-8299061-B2 | Inhibitors of diacylglycerol acyltransferase | ELI LILLY AND COMPANY (US) | 2012-10-30 | — | — | US | disclosed |
| EP-2509981-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Eli Lilly and Company (US) | 2012-10-17 | — | — | EP | disclosed |
| US-20110144091-A1 | Inhibitors of Diacylglycerol Acyltransferase | ELI LILLY AND COMPANY (US) | 2011-06-16 | — | — | US | disclosed |
| WO-2011071840-A1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | ELI LILLY AND COMPANY (US) | 2011-06-16 | — | — | WO | disclosed |
| US-20100324023-A1 | IMIDAZOBENZAZEPINE CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2010-12-23 | — | — | US | disclosed |
| WO-2010142652-A1 | IMIDAZOBENZAZEPINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISEASES | GLAXO GROUP LIMITED (GB) | 2010-12-16 | — | — | WO | disclosed |
| EP-0675889-A1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-11 | — | — | EP | disclosed |
| EP-0675887-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-11 | — | — | EP | disclosed |
| EP-0672047-A1 | ANTIALLERGIC IMIDAZO 1,2-a](PYRROLO, THIENO OR FURANO) 2,3-d]AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-09-20 | — | — | EP | disclosed |
| US-5393753-A | Antiallergens, antiinflammatory agents | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| WO-1994013671-A1 | ANTIALLERGIC TRIAZOLOBENZAZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |
| WO-1994013680-A1 | ANTIALLERGIC IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[2,3-d]AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |
| WO-1994013681-A1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-06-23 | — | — | WO | disclosed |
| EP-0577788-A1 | INSECT CONTROL WITH SUBSTITUTED OXADIAZOLE AND THIADIAZOLE COMPOUNDS | DOWELANCO (US) | 1994-01-12 | — | — | EP | disclosed |
| US-5244906-A | Miticides for rice | DOWELANCO (US) | 1993-09-14 | — | — | US | disclosed |
| WO-1993014636-A1 | INSECT CONTROL WITH SUBSTITUTED OXADIAZOLE AND THIADIAZOLE COMPOUNDS | DOWELANCO (US) | 1993-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324023-A1 | IMIDAZOBENZAZEPINE CGRP RECEPTOR ANTAGONISTS | BDKRB1, CCKBR, CALCRL | LMNA 933/4885CCR1 612/4885CCR8 941/4885 |
| US-20110144091-A1 | Inhibitors of Diacylglycerol Acyltransferase | DGAT1, DGAT2, LCAT | LMNA 4620/4885CCR1 4507/4885CCR8 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.