Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5594919 | 0.82 | HSD11B1 (0.51) | HSD11B1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL5594208 | 0.76 | ALDH1A1 (0.46) | HSD11B1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL2746882 | 0.73 | HSD11B1 (1.00) | HSD11B1RAB9AKDM4EALDH1A1 | |
| SCHEMBL12342913 | 0.72 | CYP3A4 (0.47) | HSD11B1KDM4EALDH1A1NR3C2HCAR1 | |
| SCHEMBL4730158 | 0.69 | IDO1 (0.45) | RAB9AALDH1A1KMT2APTGS2 | |
| SCHEMBL13073299 | 0.67 | IDO1 (0.46) | METHCAR1 | |
| SCHEMBL11878614 | 0.66 | AKT1 (0.41) | L3MBTL1 | |
| SCHEMBL8801286 | 0.66 | ALDH1A1 (0.37) | HSD11B1ALDH1A1P2RX7KMT2ANR3C2 | |
| SCHEMBL28317148 | 0.66 | KDR (0.43) | — | |
| SCHEMBL16113473 | 0.66 | ALOX5AP (0.48) | HSD11B1RAB9AKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880504-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997027181-A1 | HETEROCYCLO-SUBSTITUTED IMIDAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-07-31 | — | — | WO | disclosed |