Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13517925 | 0.84 | SIGMAR1 (0.45) | SIGMAR1KAT2BMAPTL3MBTL1MAPK1 | |
| SCHEMBL2388189 | 0.78 | MAPT (0.55) | MAPTL3MBTL1MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL8866289 | 0.78 | SIGMAR1 (0.56) | SIGMAR1KAT2BMAPTL3MBTL1MAPK1 | |
| SCHEMBL7568704 | 0.76 | P2RX7 (0.64) | P2RX7ALDH1A1LMNA | |
| SCHEMBL11447079 | 0.75 | ALDH1A1 (0.49) | SIGMAR1L3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8558586 | 0.74 | P2RX7 (0.47) | EPHX2MEN1KMT2AP2RX7KDM5A | |
| SCHEMBL8866420 | 0.74 | EPHX2 (0.47) | EPHX2MEN1KMT2AP2RX7KDM5A | |
| SCHEMBL8563855 | 0.73 | SIGMAR1 (0.62) | SIGMAR1MAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL9781715 | 0.72 | KAT2B (0.64) | KAT2BMAPTL3MBTL1MAPK1NPC1 | |
| SCHEMBL6198859 | 0.72 | KAT2B (0.80) | KAT2BMAPTL3MBTL1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710230-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-09-16 | — | — | EP | disclosed |
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |