Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554985 | 0.86 | ALDH1A1 (0.40) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL5274587 | 0.83 | TSHR (0.47) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8114652 | 0.81 | TSHR (0.34) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8113141 | 0.81 | GRIN2D (0.45) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8129278 | 0.80 | CAPN9 (0.33) | CAPN9CASP3 | |
| SCHEMBL8559653 | 0.79 | CES1 (0.37) | CES1 | |
| SCHEMBL8127087 | 0.79 | CAPN9 (0.31) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8112965 | 0.78 | GRIN2D (0.32) | ALDH1A1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8113118 | 0.78 | MEN1 (0.31) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL8124641 | 0.77 | TSHR (0.32) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647137-A4 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF. | UNIV CALIFORNIA WEBER ECKARD (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0647137-A1 | GLYCINE RECEPTOR ANTAGONISTS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-12 | — | — | EP | disclosed |