Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.38 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8561797 | 0.99 | ADRA1D (0.44) | ADRA1DADRA1AADRA1BADRA2AADRA2C | |
| SCHEMBL8559967 | 0.86 | PDGFRA (0.48) | RIPK2GAKCOQ8ANLKFGFR2 | |
| Hydrochloric Acid SCHEMBL8566059 | 0.85 | HTT (0.50) | RIPK2GAKCOQ8ANLKFGFR2 | |
| Water SCHEMBL8328226 | 0.85 | PDGFRA (0.47) | RIPK2GAKCOQ8ANLKFGFR2 | |
| SCHEMBL8560579 | 0.83 | POLB (0.52) | KDRGAAMAPTHPGDPOLB | |
| Hydrochloric Acid SCHEMBL8563700 | 0.82 | POLB (0.51) | KDRGAAMAPTHPGDHSD17B10 | |
| SCHEMBL8561272 | 0.77 | GAK (0.37) | RIPK2GAAGAKCOQ8ANLK | |
| SCHEMBL8562110 | 0.77 | MAPT (0.56) | GAAKDM4ELMNAMAPTHPGD | |
| SCHEMBL8560347 | 0.77 | ERBB2 (0.52) | RIPK2KDRGAAFGFR2OPRM1 | |
| Hydrochloric Acid SCHEMBL8560744 | 0.76 | GAK (0.36) | RIPK2KDRGAAGAKCOQ8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |