Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8563700 | 0.99 | POLB (0.51) | POLBTHRBMAPK10KDRSMN1; SMN2 | |
| SCHEMBL8558937 | 0.83 | ADRA1D (0.44) | POLBTHRBKDRGAAHPGD | |
| SCHEMBL8559967 | 0.82 | PDGFRA (0.48) | POLBEGFRMEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL8561797 | 0.82 | ADRA1D (0.44) | POLBTHRBKDRGAAHPGD | |
| Hydrochloric Acid SCHEMBL8566059 | 0.81 | HTT (0.50) | POLBEGFRMEN1KMT2AMAPT | |
| Water SCHEMBL8328226 | 0.81 | PDGFRA (0.47) | POLBEGFRMEN1KMT2AMAPT | |
| SCHEMBL8560347 | 0.80 | ERBB2 (0.52) | POLBTHRBKDRSMN1; SMN2TP53 | |
| SCHEMBL8327617 | 0.79 | GRM5 (0.45) | POLBTHRBMAPK10TP53MEN1 | |
| SCHEMBL810355 | 0.79 | PIK3CA (0.40) | POLBTHRBMAPK10EGFRMEN1 | |
| Hydrochloric Acid SCHEMBL8566240 | 0.79 | ERBB2 (0.51) | POLBTHRBKDRSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |