Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | RAB9A | P51151 | 2/20 | 0.82 |
| ▸ | MITF | O75030 | 1/20 | 0.82 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.64 |
| ▸ | CPT1A | P50416 | 1/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.59 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556745 | 0.92 | LMNA (0.78) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL8555897 | 0.90 | LMNA (1.00) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL10566584 | 0.86 | MEN1 (0.73) | LMNAMEN1KMT2AMAPTRAB9A | |
| Hydrochloric Acid SCHEMBL7250644 | 0.82 | LMNA (0.75) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL11794897 | 0.81 | LMNA (0.74) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL31201282 | 0.81 | ALDH1A1 (0.77) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL592889 | 0.81 | NR4A2 (0.77) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL27908679 | 0.81 | NR4A2 (0.77) | LMNAMEN1KMT2AMAPTRAB9A | |
| Acetic Acid SCHEMBL29504710 | 0.80 | MEN1 (0.71) | LMNAMEN1KMT2AMAPTRAB9A | |
| SCHEMBL9725707 | 0.80 | LMNA (0.64) | LMNAMEN1KMT2AMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| US-5693655-A | 3-indolylpiperidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-02 | — | — | US | disclosed |
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |