Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 7/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558450 | 0.88 | ANO1 (0.42) | ANO1P2RX7L3MBTL1POLBGAA | |
| SCHEMBL4425144 | 0.85 | GAA (0.44) | ANO1SHMT1SHMT2GAAMEN1 | |
| SCHEMBL6995171 | 0.82 | MEN1 (0.43) | ANO1SHMT1MEN1KMT2A | |
| SCHEMBL8651252 | 0.82 | SHMT1 (0.55) | P2RX7SHMT1SHMT2HDAC3HDAC1 | |
| SCHEMBL8557476 | 0.82 | KMT2A (0.37) | ANO1SHMT1SHMT2L3MBTL1KMT2A | |
| SCHEMBL9926531 | 0.81 | ANO1 (0.51) | ANO1P2RX7L3MBTL1POLBHDAC3 | |
| SCHEMBL8655125 | 0.80 | P2RX7 (0.44) | ANO1P2RX7SHMT1SHMT2L3MBTL1 | |
| SCHEMBL4421064 | 0.78 | MEN1 (0.42) | ANO1P2RX7L3MBTL1MEN1KMT2A | |
| SCHEMBL8558179 | 0.78 | P2RX7 (0.41) | ANO1P2RX7SHMT1SHMT2L3MBTL1 | |
| SCHEMBL4435109 | 0.76 | KMT2A (0.43) | ANO1L3MBTL1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847211-A | Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| US-5622917-A | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |