Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 2/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1733254 | 0.81 | CYP17A1 (0.73) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL28343037 | 0.80 | RECQL (0.54) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL13148562 | 0.79 | RECQL (0.54) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL12132675 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| Trimethylammonium SCHEMBL7978797 | 0.76 | CYP17A1 (0.66) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL9155908 | 0.76 | CYP19A1 (0.74) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL12088120 | 0.75 | RECQL (0.55) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL12088362 | 0.75 | RECQL (0.49) | ALDH1A1SMN1; SMN2RECQLLMNACYP17A1 | |
| SCHEMBL12218242 | 0.75 | HPGD (0.68) | ALDH1A1SMN1; SMN2RECQLCYP17A1CYP19A1 | |
| SCHEMBL8395294 | 0.74 | LMNA (0.54) | ALDH1A1SMN1; SMN2RECQLLMNAFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |