SCHEMBL8559345

SCHEMBL8559345

CC(C)Cc1s[c]nc1Cc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 4/20 0.37
SIGMAR1 Q99720 2/20 0.37
SLC18A2 Q05940 1/20 0.37
LTB4R Q15722 2/20 0.36
SLC6A2 P23975 2/20 0.35
MAOA P21397 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
CYP2A6 P11509 1/20 0.35
ADORA2A P29274 1/20 0.35
ADORA1 P30542 1/20 0.35
ALDH1A1 P00352 3/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CALM1 P0DP23 1/20 0.34
FBP1 P09467 1/20 0.33
CYP2D6 P10635 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL557935 0.70 LTA4H (0.43) LTB4RALDH1A1CALM1MEN1LMNA
SCHEMBL330644 0.69 CALM1 (0.39) LTB4RMAOAALDH1A1RAB9ASMN1; SMN2
SCHEMBL6546976 0.67 CALM1 (0.57) TAAR1SIGMAR1SLC18A2SLC6A2MAOA
SCHEMBL3185311 0.66 CALM1 (0.39) ALDH1A1RAB9ASMN1; SMN2TDP1L3MBTL1
SCHEMBL13197099 0.66 FBP1 (0.50) ALDH1A1RAB9ASMN1; SMN2FBP1HPGD
Isobutylbenzene SCHEMBL7493657 0.65 SIGMAR1 (0.64) TAAR1SIGMAR1SLC18A2SLC6A2MAOA
Isobutylbenzene SCHEMBL2571645 0.65 SIGMAR1 (0.64) TAAR1SIGMAR1SLC18A2SLC6A2MAOA
Isobutylbenzene SCHEMBL57393 0.65 SIGMAR1 (0.64) TAAR1SIGMAR1SLC18A2SLC6A2MAOA
SCHEMBL21306242 0.65 CALM1 (0.61) LTB4RALDH1A1CALM1CYP2D6HPGD
SCHEMBL26417097 0.65 MEN1 (0.45) TAAR1SIGMAR1SLC18A2SLC6A2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0821675-A1 NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1998-02-04 EP disclosed
WO-1996033176-A1 NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-10-24 WO disclosed