Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5670238 | 0.86 | HDAC1 (0.53) | HTR6KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL30483849 | 0.86 | HDAC1 (0.53) | HTR6KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL28440582 | 0.83 | KDM4E (0.57) | KMT2ARAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL31315377 | 0.83 | AKR1B1 (0.47) | MEN1KMT2ANPC1LMNAKDM4E | |
| SCHEMBL28271752 | 0.83 | HTT (0.65) | MEN1KMT2ANPC1RAB9ACYP3A4 | |
| SCHEMBL8566588 | 0.80 | HDAC1 (0.46) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL28270267 | 0.80 | KDM4E (0.60) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL8561198 | 0.80 | AGTR1 (0.56) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL28270265 | 0.80 | PKM (0.68) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL28897459 | 0.80 | AKR1B1 (0.51) | LMNAALDH1A1MAPTSMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |