Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30483849 | 0.86 | HDAC1 (0.53) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL5670238 | 0.86 | HDAC1 (0.53) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL8559792 | 0.80 | HTR6 (0.49) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL28440582 | 0.80 | KDM4E (0.57) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL28271752 | 0.80 | HTT (0.65) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL31315377 | 0.80 | AKR1B1 (0.47) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL28270267 | 0.80 | KDM4E (0.60) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL28897459 | 0.76 | AKR1B1 (0.51) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL28270265 | 0.76 | PKM (0.68) | HDAC1HDAC2HDAC8HDAC6HTT | |
| SCHEMBL8561198 | 0.76 | AGTR1 (0.56) | HDAC1HDAC2HDAC8HDAC6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |