Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365731 | 0.86 | LTB4R2 (0.57) | CES2CES1LTB4R2FOLH1BRS3 | |
| SCHEMBL29502712 | 0.86 | LTB4R2 (0.57) | CES2CES1LTB4R2FOLH1BRS3 | |
| SCHEMBL27347541 | 0.82 | FOLH1 (0.54) | CES2CES1LTB4R2BCAT2CHRNB2 | |
| SCHEMBL1041339 | 0.82 | CES2 (0.54) | CES2CES1LTB4R2BCAT2CHRNB2 | |
| SCHEMBL547673 | 0.82 | BCAT2 (0.63) | BCAT2CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL5099361 | 0.81 | SLC6A3 (0.49) | CES2CES1LTB4R2CHRNB2CHRNB4 | |
| SCHEMBL5902171 | 0.81 | BCAT2 (0.65) | CES2CES1LTB4R2BCAT2CHRNB2 | |
| SCHEMBL562 | 0.78 | SLC6A3 (0.68) | LTB4R2KMT2ATSHRBRS3 | |
| SCHEMBL29390423 | 0.78 | SLC6A3 (0.68) | LTB4R2KMT2ATSHRBRS3 | |
| SCHEMBL8916346 | 0.78 | SLC6A3 (0.48) | CES2CES1LTB4R2BCAT2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |