Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.41 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | USP19 | O94966 | 1/20 | 0.37 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.36 |
| ▸ | RXRB | P28702 | 3/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561129 | 0.87 | PTGS2 (0.44) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL8560970 | 0.87 | PTGS1 (0.43) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL8558075 | 0.86 | PTGS2 (0.43) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL7500957 | 0.85 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL8558542 | 0.84 | PTGS2 (0.43) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL8558002 | 0.84 | CA12 (0.43) | PTGS2PTGS1RXRANR4A2RXRB | |
| SCHEMBL8556142 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL8560604 | 0.82 | GRM5 (0.41) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL8558402 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1RXRAUSP1USP19 | |
| SCHEMBL8558731 | 0.81 | PTGS2 (0.47) | PTGS2PTGS1RXRAUSP1USP19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |