Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.44 |
| ▸ | USP1 | O94782 | 1/20 | 0.39 |
| ▸ | USP19 | O94966 | 1/20 | 0.39 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 4/20 | 0.38 |
| ▸ | RXRB | P28702 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556768 | 0.92 | NR4A2 (0.45) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL8559710 | 0.91 | PTGS2 (0.42) | PTGS2PTGS1USP1USP19UCHL3 | |
| SCHEMBL8555605 | 0.90 | RXRA (0.44) | PTGS2PTGS1NR4A2TRPV1RXRA | |
| SCHEMBL8558075 | 0.90 | PTGS2 (0.43) | PTGS2PTGS1USP1USP19UCHL3 | |
| SCHEMBL8555226 | 0.89 | RXRA (0.46) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL8560532 | 0.89 | RXRA (0.46) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL8558542 | 0.88 | PTGS2 (0.43) | PTGS2PTGS1USP1USP19UCHL3 | |
| SCHEMBL8556529 | 0.88 | RXRA (0.40) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL8557992 | 0.88 | ALOX5AP (0.41) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL8559954 | 0.87 | PTGS2 (0.41) | PTGS2PTGS1USP1USP19UCHL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |