Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559432 | 0.92 | MAPK1 (0.40) | RXRAMAPK1L3MBTL1LMNAPDE4A | |
| SCHEMBL8561125 | 0.92 | PTGS2 (0.47) | RXRACA4SCN9AMAPTPTGS1 | |
| SCHEMBL8561414 | 0.92 | PTGS2 (0.47) | RXRAL3MBTL1SCN9AMAPTPTGS1 | |
| SCHEMBL8559470 | 0.92 | RXRA (0.41) | RXRACA4SCN9AMAPTPTGS1 | |
| SCHEMBL8553402 | 0.87 | SCN9A (0.44) | RXRAL3MBTL1MEN1KMT2ASCN9A | |
| SCHEMBL8557954 | 0.87 | RXRA (0.47) | RXRALMNATSHRALDH1A1SCN9A | |
| SCHEMBL8556294 | 0.86 | RXRA (0.49) | RXRATSHRALDH1A1KMT2AMAPT | |
| SCHEMBL8556108 | 0.86 | RXRA (0.41) | RXRAL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL7503476 | 0.86 | PTGS2 (0.47) | MAPK1L3MBTL1LMNATSHRMEN1 | |
| SCHEMBL8560691 | 0.85 | CA1 (0.41) | RXRAMAPK1L3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |