SCHEMBL8560063

SCHEMBL8560063

CCC(NS(=O)(=O)c1ccccc1Cl)(C(=O)O)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.44
POLB P06746 1/20 0.42
SLC1A3 P43003 1/20 0.42
SLC1A2 P43004 1/20 0.42
SLC1A1 P43005 1/20 0.42
FLT1 P17948 1/20 0.42
FLT4 P35916 1/20 0.42
KDR P35968 1/20 0.42
ITGAV P06756 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8707463 0.81 CYP2C19 (0.48) ALDH1A1HTTNR3C2GAATSHR
SCHEMBL14676017 0.78 SLC1A3 (0.49) ALDH1A1POLBSLC1A3SLC1A2SLC1A1
SCHEMBL22648418 0.76 PARG (0.50) ALDH1A1POLBFLT1FLT4KDR
SCHEMBL3583413 0.72 NSD2 (0.50) ALDH1A1POLBSLC1A3SLC1A2SLC1A1
SCHEMBL878148 0.72 ALDH1A1 (0.38) ALDH1A1POLBHTT
SCHEMBL22710652 0.71 HTT (0.45) ALDH1A1HTTGAATSHRHSD17B10
SCHEMBL1969478 0.71 LMNA (0.45) ALDH1A1GAA
SCHEMBL26920833 0.71 FFAR4 (0.46) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL26920776 0.71 FFAR4 (0.46) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL14306296 0.71 KCNN4 (0.43) ALDH1A1HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3142655-B1 COMPOSITIONS AND METHODS OF TREATING CARDIAC FIBROSIS WITH IFETROBAN CUMBERLAND PHARMACEUTICALS INC (US) 2020-12-02 EP disclosed
US-5840330-A GRANULATING ACTIVE SUBSTANCE AND SUBSTANCE WHICH COMPENSATES FOR SELF-RETARDATION PROPERTIES, COMPRESSING WITH RELEASE-RETARDING AGENT SUCH THAT GRANULATE FORMS INNER PHASE AND RETARDANT OUTER PHASE BOEHRINGER MANNHELM GMBH (DE) 1998-11-24 US disclosed