Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.46 |
| ▸ | PDE4A | P27815 | 12/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669942 | 0.93 | ADORA2A (0.47) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL8563310 | 0.81 | ADORA2A (0.53) | ADORA2AADORA2BADORA1 | |
| SCHEMBL7669302 | 0.77 | ADORA2A (0.53) | ADORA2AADORA2BADORA1 | |
| SCHEMBL7661349 | 0.76 | ADORA2A (0.58) | ADORA2AADORA2BADORA1 | |
| SCHEMBL7669969 | 0.71 | ADORA1 (0.40) | ADORA2AADORA2BADORA1 | |
| SCHEMBL7671399 | 0.71 | ADORA1 (0.40) | ADORA2AADORA2BADORA1 | |
| SCHEMBL8560750 | 0.69 | PDE4A (0.52) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7025705 | 0.68 | ADORA2B (0.55) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL5005966 | 0.68 | ADORA2A (0.62) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7666660 | 0.67 | ADORA2B (0.54) | ADORA2AADORA2BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880524-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | Boehringer Ingelheim Pharma KG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1998003511-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-01-29 | — | — | WO | disclosed |