Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 3/20 | 0.45 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | MMP8 | P22894 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561005 | 0.78 | RAB9A (0.48) | ALDH1A1RAB9ANPC1MMP2MMP9 | |
| SCHEMBL30072385 | 0.71 | KMT2A (0.49) | ALDH1A1RAB9ANPC1MMP2MMP9 | |
| SCHEMBL16586271 | 0.71 | PDE10A (0.64) | ALDH1A1RAB9ANPC1MMP2MMP9 | |
| SCHEMBL17796892 | 0.71 | ALDH1A1 (0.69) | ALDH1A1RAB9ANPC1MMP2MMP9 | |
| SCHEMBL9595911 | 0.70 | RAB9A (0.65) | ALDH1A1RAB9ANPC1MMP2MMP9 | |
| SCHEMBL8561198 | 0.70 | AGTR1 (0.56) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL10451885 | 0.69 | KMT2A (0.52) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL32690191 | 0.69 | RAB9A (0.62) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL17035167 | 0.69 | RAB9A (0.51) | ALDH1A1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL12549567 | 0.68 | CYP1A2 (0.72) | ALDH1A1RAB9ANPC1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |