Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 1/20 | 0.39 |
| ▸ | USP19 | O94966 | 1/20 | 0.39 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.38 |
| ▸ | FEN1 | P39748 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556828 | 0.90 | USP1 (0.39) | USP1USP19WDR48ALOX5APFEN1 | |
| SCHEMBL8545808 | 0.86 | USP1 (0.38) | USP1USP19WDR48ALOX5APFEN1 | |
| SCHEMBL8550565 | 0.85 | NR4A2 (0.38) | USP1USP19WDR48CA12CA1 | |
| SCHEMBL9099699 | 0.84 | NR4A2 (0.39) | USP1USP19WDR48CA12CA1 | |
| SCHEMBL8558824 | 0.82 | PTGS2 (0.45) | USP1USP19ALOX5APFEN1PTGS2 | |
| SCHEMBL7499215 | 0.81 | PTGS2 (0.54) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL7508511 | 0.81 | PTGS2 (0.54) | CA12CA1CA2CA9PTGS2 | |
| SCHEMBL5694182 | 0.80 | PTGS2 (0.56) | CA12CA1CA2CA9NR4A2 | |
| SCHEMBL8561935 | 0.80 | CA12 (0.38) | USP1USP19WDR48ALOX5APFEN1 | |
| SCHEMBL9026920 | 0.79 | PTGS2 (0.41) | USP1USP19ALOX5APFEN1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |