Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 5/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25023516 | 0.84 | SIRT2 (0.48) | SIRT2SIRT1HDAC1HDAC6TP53 | |
| SCHEMBL8569448 | 0.82 | DRD2 (0.45) | TP53KDM4EHDAC8THRB | |
| SCHEMBL27485081 | 0.80 | PTGS1 (0.46) | HDAC1HDAC6KDM1AKDM4EHDAC8 | |
| Bromide SCHEMBL8565335 | 0.78 | SIRT2 (0.48) | SIRT2SIRT1HDAC1HDAC6TP53 | |
| SCHEMBL8563968 | 0.78 | HDAC8 (0.40) | HDAC1HDAC6TP53HDAC8 | |
| SCHEMBL8563972 | 0.78 | TP53 (0.37) | HDAC1HDAC6TP53ROCK2ELANE | |
| SCHEMBL3689873 | 0.78 | HRH3 (0.55) | HDAC1HDAC6KDM4ECHKAHDAC8 | |
| SCHEMBL28176279 | 0.78 | HRH3 (0.55) | HDAC1HDAC6KDM4ECHKAHDAC8 | |
| SCHEMBL15033023 | 0.76 | KDM4E (0.50) | SIRT2SIRT1HDAC1HDAC6KDM1A | |
| SCHEMBL28175300 | 0.76 | KDM4E (0.50) | SIRT2SIRT1HDAC1HDAC6KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |