Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.34 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561859 | 0.78 | SIRT2 (0.49) | TP53ROCK2ELANEHDAC1HDAC6 | |
| SCHEMBL8569448 | 0.75 | DRD2 (0.45) | TP53 | |
| SCHEMBL8563968 | 0.73 | HDAC8 (0.40) | TP53HDAC1HDAC6 | |
| SCHEMBL27485081 | 0.71 | PTGS1 (0.46) | HDAC1HDAC6 | |
| SCHEMBL16874550 | 0.69 | KCNH2 (0.51) | TP53KCNH2LMNA | |
| SCHEMBL8564264 | 0.69 | DDB1 (0.50) | HDAC1HDAC6 | |
| SCHEMBL8564268 | 0.69 | DDB1 (0.50) | HDAC1HDAC6 | |
| SCHEMBL8560205 | 0.69 | KDM4E (0.54) | KCNH2HDAC1 | |
| SCHEMBL8562132 | 0.69 | GAA (0.56) | LMNA | |
| SCHEMBL8560210 | 0.69 | KDM4E (0.54) | KCNH2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |