Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTRB1 | P17538 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 5/20 | 0.49 |
| ▸ | CTSS | P25774 | 5/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561049 | 0.94 | CTRB1 (0.55) | CTRB1SYKATMNPC1RAB9A | |
| SCHEMBL10612691 | 0.91 | CTRB1 (0.61) | CTRB1SYKATMCTSKCTSL | |
| SCHEMBL10906071 | 0.90 | ALDH1A1 (0.53) | CTRB1SYKATMNPC1RAB9A | |
| SCHEMBL10873730 | 0.88 | CTRB1 (0.58) | CTRB1SYKATMNPC1RAB9A | |
| SCHEMBL6979650 | 0.88 | CTRB1 (0.65) | CTRB1SYKATMNPC1RAB9A | |
| SCHEMBL18334515 | 0.85 | CTRB1 (0.58) | CTRB1SYKATMNPC1RAB9A | |
| SCHEMBL9192816 | 0.85 | CTRB1 (0.58) | CTRB1SYKATMNPC1RAB9A | |
| SCHEMBL10787497 | 0.84 | CTRB1 (0.60) | CTRB1ATMNPC1RAB9ACTSK | |
| SCHEMBL2949041 | 0.84 | CTSK (0.57) | CTRB1ATMNPC1RAB9ACTSK | |
| SCHEMBL2949040 | 0.84 | CTSK (0.57) | CTRB1ATMNPC1RAB9ACTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710230-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-09-16 | — | — | EP | disclosed |
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |
| US-5686449-A | 1,5-benzodiazepines useful as gastrinor CCK-antagonists | GLAXO WELLCOME S.P.A. (IT) | 1997-11-11 | — | — | US | disclosed |
| EP-0710230-A1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO S.p.A. (IT) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003285-A1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO SPA (IT) | 1995-02-02 | — | — | WO | disclosed |
| US-4090027-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1978-05-16 | — | — | US | disclosed |
| US-4077978-A | APPETITE SUPPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-3996374-A | Isoindole derivatives as appetite suppressants | HOFFMANN-LA ROCHE INC. (US) | 1976-12-07 | — | — | US | disclosed |