Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.43 |
| ▸ | EDNRB | P24530 | 3/20 | 0.42 |
| ▸ | EDNRA | P25101 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9026630 | 0.91 | HDAC6 (0.42) | HDAC6HDAC4HDAC1HSD11B1PTPN2 | |
| SCHEMBL8559926 | 0.81 | MAPT (0.47) | HDAC6HDAC4HSD11B1PTPN2PTPN1 | |
| SCHEMBL5694177 | 0.79 | EDNRB (0.51) | HSD11B1PTPN2PTPN1PTPN5EDNRB | |
| SCHEMBL8561382 | 0.78 | HSD11B1 (0.44) | HSD11B1PTPN2PTPN1PTPN5EDNRB | |
| SCHEMBL8560251 | 0.78 | HDAC6 (0.48) | HDAC6HDAC4HDAC1HSD11B1PTPN2 | |
| SCHEMBL8554887 | 0.77 | NR4A2 (0.54) | HSD11B1PTPN2PTPN1PTPN5EDNRB | |
| SCHEMBL8560089 | 0.76 | MAPT (0.58) | PTPN2PTPN1PTPN5MEN1KMT2A | |
| SCHEMBL8555072 | 0.76 | SLC40A1 (0.45) | HSD11B1PTPN2PTPN1PTPN5EDNRB | |
| SCHEMBL8558261 | 0.76 | HSD11B1 (0.44) | HSD11B1PTPN2PTPN1PTPN5EDNRB | |
| SCHEMBL8560329 | 0.75 | PTGS2 (0.52) | HSD11B1PTPN2PTPN1PTPN5EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |