Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT3 | O60678 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565760 | 0.88 | MEN1 (0.48) | DRD2DRD3GRM2DRD4LMNA | |
| SCHEMBL8568859 | 0.86 | DRD2 (0.37) | DRD2DRD3GRM2DRD4NOS3 | |
| SCHEMBL8565529 | 0.86 | GRIN2B (0.38) | DRD2DRD3GRM2DRD4KDM4E | |
| SCHEMBL9535315 | 0.82 | ALDH1A1 (0.47) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL14173615 | 0.82 | SSTR5 (0.51) | DRD2DRD3DRD4LMNA | |
| Water SCHEMBL4983352 | 0.81 | KCNH2 (0.51) | DRD2DRD3DRD4LMNA | |
| Hydrochloric Acid SCHEMBL4987342 | 0.81 | KCNH2 (0.51) | DRD2DRD3DRD4LMNA | |
| SCHEMBL8561156 | 0.81 | ALDH1A1 (0.42) | KDM4ENOS2 | |
| SCHEMBL9538432 | 0.81 | PRMT3 (0.59) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| SCHEMBL8567881 | 0.78 | MAPT (0.44) | DRD2DRD3DRD4KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539421-B1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 1998-09-23 | — | — | EP | disclosed |
| US-5278165-A | Oxazolyl imidazol[4,5-b]pyridin and pyrimidine compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-11 | — | — | US | disclosed |
| US-5217980-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-08 | — | — | US | disclosed |
| WO-1992001687-A1 | NOVEL OXAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-06 | — | — | WO | disclosed |