Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | FABP1 | P07148 | 1/20 | 0.37 |
| ▸ | FABP6 | P51161 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287260 | 0.85 | GAA (0.50) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL20054814 | 0.79 | SMN1; SMN2 (0.49) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL24938161 | 0.79 | RAB9A (0.47) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11294798 | 0.79 | KDM4E (0.51) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL19699329 | 0.75 | ALDH1A1 (0.46) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL11293577 | 0.75 | ALDH1A1 (0.52) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL5674801 | 0.73 | EHMT2 (0.52) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL149380 | 0.72 | MEN1 (0.55) | GAAALDH1A1MEN1KMT2AMAPK10 | |
| SCHEMBL22827964 | 0.69 | — | — | |
| SCHEMBL12521841 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |