Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL547673 | 0.86 | BCAT2 (0.63) | KMT2AMEN1SMN1; SMN2BCAT2GAA | |
| SCHEMBL981885 | 0.86 | CES2 (0.63) | KMT2AMEN1SMN1; SMN2BCAT2CES2 | |
| SCHEMBL31402608 | 0.85 | KMT2A (0.60) | KMT2AMEN1SMN1; SMN2BCAT2NPC1 | |
| SCHEMBL372 | 0.85 | KMT2A (0.60) | KMT2AMEN1SMN1; SMN2BCAT2NPC1 | |
| Hydrochloric Acid SCHEMBL7610390 | 0.83 | KMT2A (0.59) | KMT2AMEN1SMN1; SMN2BCAT2NPC1 | |
| SCHEMBL16882044 | 0.82 | KMT2A (0.48) | KMT2AMEN1SMN1; SMN2BCAT2CES2 | |
| SCHEMBL7745951 | 0.81 | CHEK1 (0.49) | KMT2AMEN1SMN1; SMN2BCAT2NPC1 | |
| SCHEMBL5693606 | 0.80 | AKR1C3 (0.61) | KMT2AMEN1SMN1; SMN2BCAT2CES2 | |
| SCHEMBL27438916 | 0.80 | HDAC7 (0.57) | KMT2AMEN1SMN1; SMN2BCAT2CES2 | |
| SCHEMBL6004326 | 0.79 | BCAT2 (0.71) | KMT2AMEN1SMN1; SMN2BCAT2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |