Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 6/20 | 0.30 |
| ▸ | CA1 | P00915 | 6/20 | 0.30 |
| ▸ | CA2 | P00918 | 6/20 | 0.30 |
| ▸ | CA9 | Q16790 | 6/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8629913 | 0.80 | CA12 (0.31) | CYP3A4CA12CA1CA2CA9 | |
| SCHEMBL8623666 | 0.77 | L3MBTL1 (0.35) | CYP3A4CA12CA1CA2CA9 | |
| SCHEMBL8625791 | 0.74 | ALDH1A1 (0.33) | CA12CA1CA2CA9CA14 | |
| SCHEMBL24924824 | 0.72 | CA12 (0.54) | CYP3A4CA12CA2CA9CA4 | |
| SCHEMBL27490066 | 0.69 | CA12 (0.37) | CA12CA1CA2CA9CA14 | |
| SCHEMBL27491838 | 0.66 | CA12 (0.40) | CA12CA1CA2CA9CA14 | |
| SCHEMBL8285749 | 0.65 | LMNA (0.39) | CA12CA1CA2CA9 | |
| SCHEMBL8286622 | 0.64 | CA12 (0.62) | CYP3A4EGFRERBB2CA12CA1 | |
| SCHEMBL27506106 | 0.64 | — | — | |
| SCHEMBL8629803 | 0.63 | CYP3A4 (0.39) | CYP3A4ADORA3ADORA2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | claimed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | claimed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | claimed |
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |