Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VHL | P40337 | 1/20 | 0.41 |
| ▸ | ELOC | Q15369 | 1/20 | 0.41 |
| ▸ | ELOB | Q15370 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562108 | 0.84 | AR (0.42) | VHLELOCELOBS100A4AR | |
| SCHEMBL8564785 | 0.81 | CHRNB2 (0.31) | — | |
| SCHEMBL8566794 | 0.79 | GLS (0.39) | S100A4MEN1KMT2A | |
| SCHEMBL27560253 | 0.76 | VHL (0.44) | VHLELOCELOBS100A4SRD5A1 | |
| SCHEMBL8563388 | 0.74 | AR (0.42) | VHLELOCELOBS100A4AR | |
| SCHEMBL7324722 | 0.73 | VHL (0.41) | VHLELOCELOBS100A4SRD5A1 | |
| SCHEMBL8561344 | 0.67 | ACHE (0.39) | ALDH1A1KMT2A | |
| SCHEMBL11852519 | 0.66 | KMO (0.47) | MEN1ALDH1A1CYP3A4KMT2A | |
| SCHEMBL2792252 | 0.66 | MAP4K4 (0.56) | SRD5A1MAP4K4PDE5ASRD5A2 | |
| SCHEMBL31384990 | 0.66 | AR (0.40) | VHLELOCELOBS100A4SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |