Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561061 | 0.81 | PDE10A (0.38) | DOT1LKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL8563007 | 0.73 | ADRA2B (0.37) | KDM4ENPC1RAB9AMAPTLCK | |
| SCHEMBL10426160 | 0.72 | PDE10A (0.56) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL20085840 | 0.72 | ALDH1A1 (0.38) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL10691127 | 0.72 | CYP1A2 (0.42) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL25151349 | 0.65 | ALDH1A1 (0.38) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL31240925 | 0.65 | L3MBTL1 (0.37) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL5633143 | 0.65 | ALDH1A1 (0.34) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL5634860 | 0.65 | ALDH1A1 (0.38) | KDM4ENPC1RAB9AALDH1A1PKM | |
| SCHEMBL3971488 | 0.65 | NPC1 (0.61) | KDM4ENPC1RAB9AALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0596406-B1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5750699-A | HALOGENATING OF CORRESPONDING COMPOUND | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-12 | — | — | US | disclosed |
| US-5574042-A | ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN | FUJISAWA PHARMACEUTICAL CO., LTD (JP) | 1996-11-12 | — | — | US | disclosed |
| EP-0596406-A1 | Imidazo (1,2-a) Pyridines as bradykinin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |