Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10426160 | 0.78 | PDE10A (0.56) | ALDH1A1HPGDHSD17B10PDE10AKDM4E | |
| SCHEMBL3256643 | 0.76 | ALDH1A1 (0.54) | CYP1A2CYP2A6ALDH1A1HPGDHSD17B10 | |
| SCHEMBL11250574 | 0.75 | ALDH1A3 (0.52) | ALDH1A1HPGDHSD17B10KDM4ENPC1 | |
| SCHEMBL8563007 | 0.73 | ADRA2B (0.37) | CYP1A2KDM4ENPC1RAB9AMAPT | |
| SCHEMBL8563013 | 0.72 | DOT1L (0.35) | ALDH1A1HPGDHSD17B10PDE10AKDM4E | |
| SCHEMBL8561058 | 0.72 | CYP3A4 (0.42) | CYP1A2PDE10AKDM4ENPC1RAB9A | |
| SCHEMBL10694973 | 0.71 | MAPK1 (0.47) | CYP1A2MAPTGRM5MEN1KMT2A | |
| SCHEMBL10691749 | 0.71 | POLB (0.40) | ALDH1A1HPGDNR4A2KDM4ENPC1 | |
| SCHEMBL10692077 | 0.71 | CYP1A2 (0.42) | CYP1A2CYP2A6ALDH1A1NR4A2PDE10A | |
| SCHEMBL20085840 | 0.70 | ALDH1A1 (0.38) | ALDH1A1HPGDHSD17B10PDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738967-A | Imidazoisoquinoline compounds useful as anti-ulcerative agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-19 | — | — | US | disclosed |
| US-4686227-A | Imidazoisoquinoline compounds useful as anti-ulcerative agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-08-11 | — | — | US | disclosed |
| EP-0165545-A2 | Imidazoisoquinoline compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-12-27 | — | — | EP | disclosed |