Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 9/20 | 0.50 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865968 | 0.84 | CCKBR (0.57) | CCKBR | |
| SCHEMBL8559660 | 0.81 | CCKBR (0.77) | CCKBR | |
| SCHEMBL8650565 | 0.80 | CCKBR (0.54) | CCKBR | |
| SCHEMBL8557103 | 0.72 | CCKBR (0.44) | CCKBR | |
| SCHEMBL8560348 | 0.71 | PSMB8 (0.36) | CCKBR | |
| SCHEMBL6176791 | 0.71 | NAAA (0.48) | IDO1TDO2 | |
| SCHEMBL28513970 | 0.70 | ALDH1A1 (0.52) | — | |
| SCHEMBL13130611 | 0.70 | NAAA (0.46) | IDO1TDO2 | |
| SCHEMBL6176821 | 0.70 | GAA (0.48) | IDO1TDO2 | |
| SCHEMBL7549407 | 0.69 | CCKBR (0.48) | CCKBRIDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710230-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-09-16 | — | — | EP | disclosed |
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |
| US-5686449-A | 1,5-benzodiazepines useful as gastrinor CCK-antagonists | GLAXO WELLCOME S.P.A. (IT) | 1997-11-11 | — | — | US | disclosed |